To improve the damage ability of integral multiple explosively formed projectiles (MEFP), the effect of configuration parameters of liner on projectile formation was studied using LS-DYNA code. Based on the simulating results, a integral charge structure was optimized and designed and its experiment verification was carried out.Results show that liner configuration parameters have great effect on projectile shape. With increasing the liner curvature radius, the length-diameter ratio of central projectile and the length of surrounding projectile decrease by 40% and 41.2%, respectively. The shape of surrounding projectile changes from rods to ball shape gradually. With increasing the liner thickness, the length-diameter ratio of central projectile and the length of surrounding projectile decrease by 22.2% and 19.7%, respectively. The trail of surrounding projectile decreases gradually and the flight stability of projectile enhances. The curvature radius obtained by optimization and optimal value of thickness are 77-82 mm and 2.2-2.6 mm, respectively. Designed warhead can effectively penetrate the 45^# steel target plate with a thickness of 15 mm, which is in good agreement with the simulation results.