In order to reduce the mechanical sensitivity of hexanitrohexaazaisowurtzitane（CL-20）， the co-crystal explosives CL-20/3-MNP （co-crystal 1） and CL-20/4-MNP （cocrystal 2） were prepared by cocrystal technology by combining the isomeric molecules of CL-20 and methyl-nitropyrazole（MNP）：1-methyl-3-nitropyrazole（3-MNP） and 1-methyl-4-nitropyrazole （4-MNP）. The structure of the single crystal was determined by single crystal X-ray diffractometer （SXRD）， and the thermal properties and impact sensitivity of the cocrystal were measured by differential scanning calorimetry （DSC） and BAM drop weight impact sensitivity instrument， and the detonation performance was predicted by EXPLO5. The results show that cocrystal 1 is a triclinic crystal system with a P space group. Cocrystal 2 is an orthorhombic crystal system with a Pbca space group. The melting points of cocrystal 1 and cocrystal 2 are 113.2 ℃ and 147.2 ℃， respectively， which are 25.2 ℃ and 53.7 ℃ higher than those of 3-MNP and 4-MNP， respectively， and the decomposition temperature is higher than that of CL-20， which has better thermal stability， and the impact sensitivity of cocrystal 1 and cocrystal 2 is 20 J and 18 J， respectively， which effectively reduces the sensitivity of CL-20 （2.5 J）. The theoretical detonation velocity is 8060 m·s^-1 and 8643 m·s^-1， and the theoretical detonation pressure is 26.16 GPa and 32.61 GPa， respectively， which are lower than those of CL-20， and the cocrystal 2 sensitivity and detonation performance are comparable to those of LLM-105（17 J， 8560 m·s^-1， 34.99 GPa）， which is expected to be used as a new high-energy and low-inductance cocrystal explosive.