To achieve the crystallization regulation and batch production of explosives at the safety-critical scale， the ZS-1 microfluidic crystallization system was established based on the microfluidic technology. The experiments were carried out with DMSO as the solvent and deionized water as the anti-solvent. By changing the crystallization process parameters such as the two-phase flow rate ratio， explosive concentration and total flow rate， the particle size control of RDX and the polymorphic transformation of HMX at the microscale was studied， and high-throughput screening of crystallization parameters was explored. Batch preparation experiment of micron RDX was carried out on the ZS-1 microfluidic system. The results show that the average paritcle size of RDX is deduced by 22.2 times after recrystallization. Specifically， the D₅₀ of RDX samples is 3.35 μm， the SPAN number is 0.956 and the purity is 99.80%， and the hourly output of single system reaches 207.7 g. The ZS-1 microfluidic crystallization system verifies the feasibility of batch preparation of narrow size-distributed micron explosives at the microscale.