To investigate the influence of SiC mass fraction， SiC particle size， Al particle size， and their interactions on the mechanical properties of PTFE/Al/SiC （PAS） reactive materials， a 2³ factorial design criterion was employed to design and prepare eight different compositions of PTFE/Al/SiC reactive materials， and quasi-static compression tests and split Hopkinson pressure bar （SHPB） experiments were conducted. Significant factors were selected using the t-value ranking method， and their contribution rates and disturbance trends were analyzed. Additionally， response surface methodology was employed to analyze significant interaction effects. The results indicate that a higher SiC mass fraction positively impacts the mechanical properties of PAS materials. With a sudden change of strain rate， SiC particle size exhibits opposite disturbance trends on the material mechanical response. The effect of Al particles on the mechanical response of the PAS material system is limited. Strong interaction effects between factors should not be overlooked. With low strain rate loading， the interaction between SiC mass fraction and SiC particle size is significant. When the SiC mass fraction is high and the particle size is small， the particle dispersion state and interfacial bonding strength can be optimized， thereby improving material mechanical response. With high strain rate loading， PAS materials with a higher SiC mass fraction exhibit higher dynamic mechanical response， and the interaction between SiC particle size and Al particle size is significant. When the particle sizes of SiC and Al are close， the dynamic response of the material can be effectively improved.