Using droplet microfluidics technology， an aqueous solution of the active agent at a concentration of 0.5% was used as the continuous phase， and an ethyl acetate solution of DAAF was employed as the dispersed phase. DAAF/F2602 composite microspheres were prepared by fluid-focused microchanneling. The effects of two-phase flow rate ratio， concentration of dispersed phase， and type of active agent on particle morphology， particle size， and roundness of DAAF/F2602 composite microspheres were investigated. The optimal process conditions， including a suspension concentration of 4%， a two-phase flow rate ratio of 16∶1 and an active agent of CTAB， were obtained and compared with the aqueous suspension method. The results show that the DAAF crystalline shape of the samples obtained from two preparation methods are unchanged， the impact sensitivity is higher than 100 J， and the friction sensitivity is 0% and the friction sensibility are more than 360 N， indicating that the two samples have good safety performance. Among them， the particle sizes of DAAF/F2602 composite microspheres which obtained by the droplet microfluidization method were in the range of 20.22 to 53.85 μm， which were smaller than that obtained by the aqueous suspension method （121-356 μm）.Furthermore， the particle sizes distribution was observed to be more uniform. Thethermal decomposition exhibited a delayed peak temperature by 6.45 ℃， and the activation energy was increased by 6.12 kJ·mol^-1， which lead to improved thermal stability. The cone angle generated by the stacking of DAAF/F2602 composite microspheres which obtained by the droplet microfluidization method， is 34°. This angle is smaller than that of composite particles obtained by the water suspension method （40°）， which indicate better dispersion property.