To investigate the thermal hazards of the synthetic reaction process of FOX-7， the heat flow curve of the hydrolysisinvolved therein has been measured by using Reaction Calorimeter （RC1）. The n^th-order kinetic models were applied to different temperature systems and the apparent kinetic parameters of these processes were obtained. The results indicated that the exothermic heat of the synthesis reaction was -46.563 kJ∙mol^-1， and the adiabatic temperature rise was 9.1 K. Under the thermal runaway chemical reaction condition， the maximum temperature of the synthesis reaction （MTSR） is 29.1 ℃. The reaction order is 1.21 for synthesis of 2-（dinitromethylene）-5，5-dinitrodihydropyrimidine-4，6-dione. The activation energy （E_a） of the reaction is 73.2 kJ∙mol^-1， with the pre-exponential factor of 5.03×10⁹ s^-1.