In order to compare the comprehensive properties of 2,4-dinitroanisole(DNAN)-based and 2,4,6-trinitrotoluene（TNT） -based melt-cast explosives, the suspension rheology, performance, safety and mechanical properties of typical TNT-based and DNAN-based explosives were systematically investigated by experiment tests. The viscosity of DNAN(6.87 mPa·s) was lower than that of TNT(9.05 mPa·s), which made the limit solid content of the DNAN/HMX melt-cast system (about 80%) higher than that of the TNT/HMX melt-cast system (about 75%). The detonation velocity and detonation pressure was 8336 m·s^-1 and 31.03 GPa, 8452 m·s^-1 and 31.44 GPa, for DNAN/HMX(20/80) and TNT/HMX(25/75), respectively. The response level of DNAN/HMX(20/80) and TNT/HMX(25/75) was burning and explosion, respectively under 1 K·min^-1 slow cook-off. Under 4.51 GPa incident shock wave pressure, TNT/HMX(25/75）achieved complete detonation within 8-12 mm, whereas DNAN/HMX(20/80) failed to achieve complete detonation within 12 mm; tensile and compressive strength of DNAN/HMX(20/80) was higher than that of TNT/HMX(25/75).With basically equal energy performance, DNAN/HMX(20/80) melt-cast explosives have better safety and mechanical properties than TNT/HMX（25/75） melt-cast explosives.