The constitutive relationship of polymer bonded explosive (PBX) including damage is one of the key fundamental issues of the safety research of PBX. To study the damage constitutive relationship of PBX explosive, it is necessary to accurately acquire and understand the dynamic mechanical response of PBX explosive.. Therefore, in allusion to the SHPB tests on PBX, it is particularly discussed that the influence of loading ways on the mechanical response of PBX. Through different shapers, loading wave length, and repeated loading, the influences of different loading ways on the mechanical response including damage of PBX have been analyzed, and a series of stress-strain curves were obtained. The ultimate damage morphology of recycled samples was observed by scanning electron microscopy, and the damage development process of PBX explosive under dynamic uniaxial compression and its performance in stress-strain relationship were analyzed.. Results show that loading with brass shaper leads to large strain acceleration and still has an impact on PBX, resulting in additional damage. The failure of specimens subjected to dynamic uniaxial compression is characterized by multiple transgranular fracture or even fragmentation of crystals. The constitutive relationship considering damage can be described by the nucleation, stable growth, and unstable propagation through crystals of micro-cracks.