In order to explore the interaction between the optimal technologic conditions and influencing factors of high gravity-enhanced heterogeneous catalytic ozonation for phenol mineralization, response surface methodology (RSM) was used to optimize the experiment. According to the principle of Box-Behnken Design （BBD） center combination design, four-factor and three-level experiments were designed. The effect of high gravity factor (β), initial pH, liquid flow rate (Q_L), ozone concentration (C_O3) on the mineralized phenol wastewater was investigated. The mathematical model of the technology was established and the optimized technologic parameters were determined. Results show that there is an extremely significant interaction between β and initial pH, and a significant interaction between β and Q_L. The optimal technologic parameters are as follows: β is 60, initial pH 5.47, C_O3 62.5 mg·L^-1, and Q_L 89.95 L·h^-1. The predicted value is 91.54%, 0.97% (<2%) higher than the measured value. It can be concluded that the obtained secondary mathematical model for the phenol mineralization via high gravity-enhanced heterogeneous catalytic ozonation has a good reliability for the optimization of technologic conditions and prediction of mineralization rate of phenol wastewater. In addition, the coupling between high gravity technology and heterogeneous catalytic ozonation technology is beneficial to the formation of OH radical, which reacts with organics, from the rapid decomposition of ozone in liquid phase. Thus, the phenol mineralization via high gravity-enhanced heterogeneous catalytic ozonation follows OH mechanism, and the phenol wastewater could be completely mineralized within 30 min.