To realize high safety and intelligent control of ordnance initiation system, an addressable initiation network system based on RS485 bus was designed by means of bus networks topological structure and protocol coding addressing. The design of integrate energy conversion element of smart initiator embedded in “identity address” and its safety, system data interaction protocol and working mechanism were emphatically studied. The feasibility and safety of the system addressing control were tested and verified. Results show that the system can realize the multi-mode addressing control initiation of 255 smart initiators. The multi-point synchronous initiation has good synchronization, and the system has the characteristics of intellectualization and high safety.