Using a typical 2,4-dimitroanisole(DNAN) based thermoplastic melt-cast explosive MX-2 the influence of main process factors and important degree of various factors on mean charge density, density difference and ingredient uniformity of the MX-2 were investigated by orthogonal experiments. Results show that the slurry temperature, vacuum pumping time and vacuum are major factors influencing the charge quality. The order of significant influence is: vacuum treatment time > vacuum degree > slurry temperature. The optimal conditions of charge process are as follows: vacuum treatment time 15 min, the vacuum degree -0.090 MPa and the slurry temperature 95 ℃.