Molecularly imprinted polymer (MIP) microspheres were prepared via precipitation polymerization with hexanitrohexaazaisowurtzitane(CL-20) as template, acrylamide as functional monomer, trimethylolpropane triacrylate as crosslinking agent, acetonitrile as solvent and porogen and 2, 2-azobisisobutyronitrile (AIBN) as initiatives using molecularly imprinted technology (MIT). The optimum synthetic conditions were obtained as follow: the molar ratio of the template, functional monomer and crosslinking agent was 1:7:20 and the experiment temperature was 60 ℃. The synthesized polymer microspheres are regularly spheres and their diameter is about 1 μm. The interaction between the CL-20 and the function monomer was determined by UV-visible adsorption spectrum, and the microstructures of CL-20/MIP and NMIP were observed by scanning electron microscope (SEM). Results show that the CL-20 interacts with the functional monomers, and CL-20/MIP microspheres have good sphericity and are independent to each other, while a certain degree of reunion phenomenon is found in the NMIP microspheres. The recognition capability studied by equilibrium binding experiment show that the equilibrium binding capacity of the microspheres is 14.02 mg·g^-1 in CL-20/alcohol solution with the concentration of 0.4 mmol·L^-1, while the binding capacity of NMIP is 6.77 mg·g^-1. The amounts of RDX and TNT adsorbed by CL-20-MIP in selective binding experiments is 6.98 mg·g^-1 and 8.46 mg·g^-1, respectively, indicating MIP possesse recognition property of CL-20. The adsorption thermodynamics shows that CL-20-MIP and NMIP have good adsorption property and are accord with Freundlich adsorption isotherm. Studies of adsorption kinetics show that the adsorption of CL-20-MIP can simulate by pseudo-first order and pseudo-second order kinetics models, but the latter equation is better.