To analyze the jet impact sensitivity of the new high-energy insensitive explosive 2, 6-diamino-3, 5-dinitropyridine-1-oxide(ANPyO), the jet initiation sensitivity test of unconfined explosive ANPyO and 8701 covered by 45^# steel barrier under the conditions of shaped charge with diameter of 56 mm and stand off of 80 mm was performed. The critical thickness of barrier was obtained by Langlie method, the critical head velocity and diameter of jet were calculated by AUTODYN, the critical initiation threshold I_cr was calibrated and comparison of the test results of ANPyO with the test ones of 8701 explosive was carried out. Results show that under the critical detonation, the critical thickness of 45# steel barrier covering 8701 explosive is about 160 mm and for ANPyO explosive is about 68 mm, which reduces by about 57.5%. The critical velocity of ANPyO is 3.7 mm·μs^-1. The head diameter of jet for ANPyO is 4.8 mm. The initiation threshold I_cr of ANPyO is about 32.3 mm³·μs^-2, which is four times than 8701 explosive; revealing that ANPyO is much more insensitive than 8701 explosive, and it is a kind of explosive with low jet initiation sensitivity.