To study the lethality of azimuthal warhead, a fragment muzzle velocity formula used in limited angles of extension line opposite to azimuthal detonating point of azimuthal warhead was deduced, and tungsten cylinder fragment and tungsten sphere fragment azimuthal warheads were designed to validate the model by experiments. Results show the formula can be used to the calculation of azimuthal warhead. The designed azimuthal warhead velocity gain is 10.9% for tungsten cylinder fragment and 19.8% for tungsten sphere fragment. The muzzle velocity, sphere distribution density and killing probability of tungsten sphere fragment are better than those of the tungsten cylinder fragment.