Furazano[3, 4-e]-1, 2, 3, 4-tetrazine-1, 3-dioxide(FTDO) has been synthesized in the work. Firstly, diaminoglyoxime(DAG) was obtained via the one-step reaction of glyoxal with hydroxylammonium chloride. 3, 4-Diaminofurazan(DAF) was obtained by the dehydration reaction of DAG. Then the oxidation of DAF using 30% H₂O₂ gave 3-amino-4-nitrosofurazan(ANF), and 3-amino-4-(tert-butyl)azoxyfurazan was prepared after the treatment of ANF with tert-butyl-N, N-dibromide in dichloromethane. Finally, FTDO was obtained by the nitration and cyclization of 3-amino-4-(tert-butyl)azoxyfurazan with nitronium tetrafluorobrate (NO₂BF₄) in acetonitrile with the total yield of 18%. The structures of FTDO and its intermediates were characterized by IR and NMR.