5-Amino-3-nitro-1, 2, 4-triazole (ANTA) was important propellant as an insensitive explosive. The impact insensitivity of ANTA was higher than 320 cm(Type12), and its the detonation velocity was about 8460 m·s^-1 (ρ=1.819 g·cm^-3). In addition, the structure of ANAT has two reaction centers, -NH and -NH₂, which take part in many reactions such as alkylation, arylation, diazotizotion, oxidation, ionization and so on and can be an intermediate with various compounds to synthesis many insensitive high explosives. This review focused on structure characteristics, synthesis routes and the reactive sites of ANTA. A general summany was also made on the reaction rules of ANTA to provide a reference for synthesising new insensitive high energitic materials or high nitrogen energetic salts.