The heat release law of the synthesis process of ADN was determined using reaction calorimeter RC1e. The technical process comprises four stages: neutralization, mixing of nitric acid and sulfuric acid, nitration under lower temperature and amination. At the same time, the reaction thermodynamic data including heat transfer coefficient, heat capacity were determined. Results show that, with the corresponding reaction system, the reaction heat of four stages are 580, 43.07, 207.1, 302.99 kJ, and the average heat release rate are 188.44, 12.22, 33, 125.41 W, and the adiabatic temperature rise(ΔT_ad) are 123.25 K, 19.40 K, 126.53 K and 91.48 K.