In order to explore the hazard property of the RDX-CMDB propellant prepared by screw-extrusion technique， typical experiments including friction sensitivity, impact sensitivity, detonator sensitivity, gap, deflagration-to-detonation transition (DDT), drop, thermal stability,explosion temperature, slow cook-off, and electrostatic sensitivity were carried out. Results show that the propellant does not combust dropping freely from 10 m height, combusts under 164.2 ℃ during slow cook-off test, and detonats under 18 mm-thick organic glass by the shock-wave, and the friction sensitivity and 50% drop height of impact sensitivity was 2% and 26.3 cm, respectively, and the 50% ignition energy by electrostatic spark is 208.46 mJ, which indicating that the propellant has fair thermal stability,is insensitive to the mechanical stimulation, and is sensitive to shock-wave stimulation. The hazard rating of the propellant is 1.1.