Abstract:2,6Diamino3,5dinitropyridine1oxide (ANPyO) was synthesized using 2,6diaminopyridine as the starting materials in two steps including nitration and Noxidation. The yields of nitration reaction and Noxidation reaction are 90% and 84%, the overall yield of ANPyO is 75%, which indicate that it is a better method than the method RitterLicht reported(45%). The detonation velocity(7000 m·s-1, 1.50 g·cm-3), exthermic peak (365 ℃) on the DSC curve, 5 s delay explosion point (>400 ℃), friction sensitivity (>360 N) and impact sensitivity (250 cm) for ANPyO were studied. Results show that ANPyO and 1,3,5triamino2,4,6trinitrobenzene (TATB) are about equal in the detonation and safety property, so ANPyO will be a new promising insensitive explosives in the energetic materials field.