The solubility of carbohydrazide (CHZ) in deionized water, N,N-dimethylformamide, absolute ethanol, acetic acid and chloroform at 298.15 K were studied. Integral enthalpies of dissolution and thermokinetics of the dissolution reactions of CHZ in deionized water, acetic acid glacial were measured by using a SETARAM C80Ⅱ microcalorimeter, the differential enthalpies of solution, the standard heat effects, the rate constants and the reaction orders were all obtained: 19.60 and -6.880 kJ·mol^-1; -2.79×10^-2 and 1.16×10^-2 J; 2.721×10³ and 1.888×10³ s^-1; 0.778 and 0.610.