By using nonlinear finite element analysis software LS-DYND, the process of warhead oblique penetrating the target with various impacting velocity, impacting angle, and material property is calculated and analyzed. It was found that the penetration property of warhead can be improved by increasing the material plastic flow stress and material ductibility and adjusting flight position when warhead penetrates the target. The numerical simulation results show that the deformation of warhead reduces while the front parts of the missile pre-impact the target.