Comparison studies of the initial velocity,bore pressure and the leavings after shooting of double-base ball propellant with that of D25 propellant were made by firing tests. The results show that the double-base ball propellant is better at ballistic performance,shooting stability and safety reliability. After analyzing various double-base ball propellants with different size,density and formula in 9 mm pistol ammunition,it is proved that the replacement of D25 propellant with the double-base ball propellant is reliable and feasible.