An improved method for the preparation of pentaerythrityl tetramine was reported.Pentaerythrityl tetrabromide was first prepared starting from pentaerythritol via two steps. Pentaerythrityl tetrabromide was then treated with sodium p-toluenesulphonamide to give an intermediate, which was converted to pentaerythrityl tetramine (2,2-diamnomethyl-1,3-propanediamine) disulfate. The overall yield was 30%. The effects of reaction condition, solvent and phase transfer catalyst on the reaction were discussed.