2,6Diamino3,5dinitropyridine1oxide (ANPyO) was synthesized using 2,6diaminopyridine as the starting materials in two steps including nitration and Noxidation. The yields of nitration reaction and Noxidation reaction are 90% and 84%, the overall yield of ANPyO is 75%, which indicate that it is a better method than the method RitterLicht reported(45%). The detonation velocity(7000 m·s^-1, 1.50 g·cm^-3), exthermic peak (365 ℃) on the DSC curve, 5 s delay explosion point (>400 ℃), friction sensitivity (>360 N) and impact sensitivity (250 cm) for ANPyO were studied. Results show that ANPyO and 1,3,5triamino2,4,6trinitrobenzene (TATB) are about equal in the detonation and safety property, so ANPyO will be a new promising insensitive explosives in the energetic materials field.