2-甲基-6-硝基苯胺的合成工艺研究-Synthesis Technique of 2-Methyl-6-nitroaniline

2-甲基-6-硝基苯胺的合成工艺研究

2009,17(1):4-6

1.北京理工大学生命科学与技术学院,北京 100081;2.北京理工大学材料科学与工程学院,北京 100081

摘要：研究了2-甲基-6-硝基苯胺的合成方法及工艺。以邻甲苯胺为原料,改进了原有乙酰化、硝化一锅煮的方法,采用乙酰化和硝化反应分步实施的路线进行合成。用红外、核磁、质谱等对2-甲基-6-硝基苯胺及其中间体2-甲基乙酰苯胺进行了结构表征。结果表明,改进方法工艺稳定,硝化反应温度容易控制,2-甲基-6-硝基苯胺产率最高为59.4%,纯度为99.68%。

关键词：有机化学; 2-甲基-6-硝基苯胺; 2-甲基-4-硝基苯胺; 合成

Synthesis Technique of 2-Methyl-6-nitroaniline

QI Lei¹, PANG Si-ping¹, SUN Cheng-hui²

1.School of Life Science and Technology,Beijing Institute of Technology,Beijing 100081,China;2.School of Materials Science and Engineering,Beijing Institute of Technology,Beijing 100081,China

Abstract：The synthesis technique of 2-methyl-6-nitroaniline was studied. In previous method, acetylation and nitration of 2-methylaniline were completed in one pot, but the nitration reaction temperature was difficult to be controled. To improve the method, the acetylation and nitration were detached into two parts. The structure of the product, its by-product and its intermediate were characterized by IR,NMR and MS. The results show that the temperature of nitration process can be controlled easily,and the yield is 59.4% and the purity is up to 99.68%.

Key words：organic chemistry; 2-methyl-6-nitroaniline; 2-methyl-4-nitroaniline; synthesis

收稿日期：2008-04-21

基金项目：国家自然科学基金(No. 20772011)和国家自然科学基金与中国工程物理研究院联合基金(No. 10576002)资助项目

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